Yes you can, You need to first contact HMRC and ask them to delete the CIS Return of the desired period from their record. 

Once done you may delete the HMRC submitted CIS return by following this navigation.

Navigation: Bookkeeping>> Select Client >> CIS>>CIS300>>Action Drop down>>click on delete 

From then you may prepare and submit another CIS return for the same period again and submit it to HMRC. 

We would further recommend you to please download the response of HMRC from the action drop-down before deleting any return. 

Please click to find out more about CIS in Capium